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KMID : 0606319930090010051
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Journal of Phamacetical Sciences Sookmyung Women s University
1993 Volume.9 No. 1 p.51 ~ p.62
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Effect of a new platinum complex, tetrachloro-[bis(2-chloroethyl)ethylenediamine-N,N']platinum(IV) and cisplatin on the immune response in mice
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표명윤
유경미/최지선/오현정
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Abstract
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Abstract:
@EN Effects of a new platinum complex, tetrachloro-[bis(2-chloroethyl) ethylenediamine-N,N']platinum(IV)[PtCl4-2(CEen)] and cisplatin on the immune response were investigated. Male ICR mice were treated at the respective LD50(20% or 60% LD50) of
cisplatin and PtCl4-2(CEen).
@ES The results were as following:
@EN LD50 of PtCl4-s(CEen) for male ICR mouse was 122.5mg/kg(i.p.) and higher than cisplatin(16.3mg/kg, i.p.).
Body-, spleen-, thymus,-, liver-weight, number of WBC and RBC were reduced dependently on the dose and day of administeration of cisplatin and PtCl4-2(CEen). But these toxicities produced by PtCl4-2(CEen) appeared to be relatively less and to
improve
faster than by cisplatin.
The titers of hemagglutinin and hemolysin to SRBC in mice received cisplatin and PtCi4-2(CEen) were decreased significantly and independently on the day of antigen injection.
Cisplatin and PtCl4-2(CEen) stimulated significantly contact hypersensitivity to DNFB when administered prior to sensitization(DNFB), but suppressed slightly when administered after sensitization.
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KEYWORD
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